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Disease Information, Treatments and Possible Cures
High Cholesterol (Hypercholesterolemia)

High cholesterol is excess levels of cholesterol in the blood. Cholesterol in the blood consists of three main components:

Low Density Lipoproteins (LDL) – involved in depositing cholesterol and other fats throughout the body. High levels of LDL put you at risk for hardening of the arteries and heart disease.

High Density Lipoproteins (HDL) – involved in eliminating cholesterol and other fats from the body. High levels of HDL are protective against heart disease.

Triglycerides – a common form of fat in the body

Causes

Causes of high cholesterol include:

  • Inherited tendency to have high cholesterol

  • High-fat diet

  • Overweight

  • Sedentary lifestyle

  • Excess alcohol intake

Risk Factors

A risk factor is something that increases your chance of getting a disease or condition. Risk factors for high cholesterol include:

  • Age: cholesterol levels tend to rise as you get older

  • Sex:

    • Males

    • Females after menopause

  • Family members with high cholesterol

  • High-fat diet

  • Obesity, overweight

  • Sedentary lifestyle

Symptoms

High cholesterol rarely causes symptoms.

Eventually, symptoms may include:

  • Angina (chest pain)

  • In people with an inherited form of high cholesterol, cholesterol deposits:

    • In the tendons

    • Under the eyes

    • Around the cornea

Diagnosis

The doctor will ask about your symptoms and medical history, and perform a physical exam. High cholesterol is diagnosed through tests that measure levels of the following factors in your blood:

  • Total cholesterol

  • HDL cholesterol

  • LDL cholesterol

  • Triglycerides

Treatment

Treatment may include:

Lifestyle Changes

  • Limit the amount of fat and cholesterol you eat.

  • Eat a diet high in fiber.

  • Begin a safe exercise program recommended by your doctor.

  • Increase physical activity in your daily life, as recommended by your doctor.

  • If you smoke, quit.

  • If you are overweight, lose weight.

  • Limit the amount of alcohol you drink. Moderate alcohol intake is no more than two drinks per day for men and one drink per day for women.

Cholesterol-lowering Medication

If diet and exercise don't lower your blood cholesterol in a reasonable period of time, you may need cholesterol-lowering medication. A partial list of medications includes:

  • Cholestyramine (Questran)

  • Colestipol (Colestid)

  • Nicotinic acid (Niacor)

  • Lovastatin (Mevacor)

  • Pravastatin (Pravachol)

  • Simvastatin (Zocor)

  • Atorvastatin (Lipitor)

Prevention

To reduce your chance of having high cholesterol:

  • Eat a healthful diet, one that is low in saturated fat and rich in whole grains, fruits, and vegetables.

  • Exercise regularly.

  • Maintain a healthy weight.

  • Don't smoke. If you smoke, quit.

  • Drink alcohol in moderation.

RESOURCES:

American Heart Association
http://www.americanheart.org

National Heart, Lung, and Blood Institute
http://www.nhlbi.nih.gov

CANADIAN RESOURCES

Heart and Stroke Foundation of Canada
http://ww2.heartandstroke.ca/Page.asp?PageID=24

University of Ottawa Heart Institute
http://www.ottawaheart.ca/UOHI/Welcome.do

References:

American Heart Association website. Available at: http://www.americanheart.org.

National Heart, Lung, and Blood Institute website. Available at: http://www.nhlbi.nih.gov.

Primary Care Medicine. 4th ed. Lippincott Williams & Wilkins; 2000.

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