Bohemond IV of Antioch (d. 1233), also know as the One-Eyed, was ruler of the principality of Antioch (a crusader state) between 1201 and 1216, and again from 1219 until his death. He was also count of Tripoli from 1187.

Bohemond IV was the son of Bohemond III of Antioch by his first wife Orguilleuse d'Harenc. The first part of his rule was marked by internal dynastic conflicts. Bohemond III had grandson, Raymond-Roupen of Antioch, from his eldest son Raymond of Antioch, who was considered by many to be the rightful heir to Antioch. Despite the fact that Raymond-Roupen was excluded from the succession, Bohemond IV lost the principality to his nephew, supported by Leo II of Armenia, between 1216 and 1219.

Bohemond proved to be an erractic ally, changing his vows of fidelity in whichever way he considered the best interest for his principality. An example was first the alliance then desertion of the troops of Frederick II Hohenstauffen, during the Sixth Crusade of 1228/1229. He was also a fierce enemy of the Knights Hospitaller and due to this he was excommunicated in 1230 by Pope Gregory IX.

Bohemond married Plaisance of Gibelet and had at least three sons: Henry of Antioch (father of king Hugh III of Cyprus and I of Jerusalem), Philip of Antioch, who married Isabella of Armenia, and Bohemond, who succeeded him.